2ND MALIGNANCIES FOLLOWING TREATMENT IN NON-HODGKINS-LYMPHOMA

被引：34

作者：

ELLIS, M ^{[1
]}

LISHNER, M ^{[1
]}

机构：

[1] MEIR HOSP,DEPT MED A,IL-44281 KEFAR SAVA,ISRAEL

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 9卷 / 4-5期

关键词：

NON-HODGKINS LYMPHOMA; ANLL; SOLID TUMORS;

D O I：

10.3109/10428199309148531

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Second malignancies represent an important iatrogenic complication of the treatment of hematologic and other neoplasms. In this review we summarize the literature relating specifically to malignancies developing in the wake of treated non-Hodgkin's lymphoma (NHL). In these patients, the risk of myelodysplastic syndrome (MDS) and acute non lymphocytic leukemia (ANLL) is reported to be increased 10-105 fold over that of the general population. Factors in the development of MDS and ANLL include basic defects in cellular immunity in NHL patients as well as treatment with alkylating agents and low dose total body irradiation. Biologically these secondary MDS and ANLLs are characterized by specific cytogenetic abnormalities and results of treatment are poor. Currently bone marrow transplantation offers the only potential cure. There is no clear statistical evidence that solid tumors occur more frequently after NHL. However, bladder carcinoma, in cyclophosphamide treated patients, and lung cancer have been reported by some to occur with an increased incidence. Further investigation of the molecular events leading to the occurrence of second malignancies in NHL patients and the role played by oncogenes and tumor suppressor genes in this process is still needed.1

引用

页码：337 / 342

页数：6

共 50 条

[1]

Pedersen-Bjergaard J., Therapy-related acute non-lymphocytic leukemia: Clinical aspects, Med. Oncol. Tumor Pharmacother, 5, pp. 207-209, (1988)

[2]

Tucker M.A., Coleman C.N., Cox R.S., Varghese A., Rosenberg S.A., Risk of second cancers after treatment for Hodgkin's disease, N. Eng. J. Med, 318, pp. 76-81, (1988)

[3]

Lishner M., Prokocimer M., Ron E., Et al., Primary malignant neoplasms associated with chronic lymphocytic leukemia, Postgrad. Med. J, 63, pp. 253-256, (1987)

[4]

Neglia J.P., Meadows A.T., Robinson C., Et al., Second neoplasms after acute lymphoblastic Leukemia in childhood, N. Eng. J. Med, 325, pp. 1330-1336, (1991)

[5]

Pedersen-Bjergaard J., Ersboll J., Sorensen H.M., Niles K., Larsen S.O., Philip P., Risk of acute nonlymphocytic Leukemia and preLeukemia in patients treated with cyclo-phosphamide for non-Hodgkin's lymphoma, Ann. Intern. Med, 103, pp. 195-200, (1985)

[6]

Greene N.H., Young R.C., Merrill J.M., DeVita V.T., Evidence of a treatment dose response in acute nonlymphocytic leukemias which occur after therapy of non-Hodgkin's lymphoma, Cancer Res, 43, pp. 1891-1898, (1983)

[7]

Zarrabi M.H., Association of non-Hodgkin's lymphoma and second neoplasms, Sem. Oncol, 7, pp. 340-351, (1990)

[8]

Rosner F., Cancer and secondary leukemia, Bull. Cancer (Paris), 70, pp. 55-60, (1983)

[9]

Zarrabi M.H., Association of non-Hodgkin's lymphoma and second neoplasms, Sem. Oncol, 17, pp. 120-132, (1990)

[10]

O'Donnel J.F., Brereton H.D., Greco A.F., Gralnick H.R., Johnson R.F., Acute nonlymphocytic Leukemia and acute myeloproliferative syndrome following radiation for non-Hodgkin's lymphoma and chronic lymphocytic leukemia: Clinical studies, Cancer, 44, pp. 1930-1938, (1979)

← 1 2 3 4 5 →