CHRONIC CAFFEINE EXPOSURE ENHANCES ADENOSINERGIC INHIBITION OF CEREBRAL CORTICAL-NEURONS

被引：12

作者：

LIN, Y ^{[1
]}

PHILLIS, JW ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PHYSIOL,540 E CRANFIELD,DETROIT,MI 48201

来源：

BRAIN RESEARCH | 1990年 / 520卷 / 1-2期

关键词：

Adenosine; Cerebral cortex; Chronic caffeine; Inhibition; Up-regulation;

D O I：

10.1016/0006-8993(90)91722-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic administration of caffeine (s.c. for a period of 14 days in escalating doses of 10-70 mg/kg) increased the sensitivity of rat cerebral cortical neurons to the inhibitory action of microiontophoretically applied adenosine. The sensitivity of spontaneously firing rat cerebral cortical neurons in caffeine-treated animals was compared with that of saline-treated controls using the same multiple-barrel micropepettes tested on the same day. Adenosine sensitivity was determined by the I·T50 method. The I·T50 value for 134 neurons in the caffeine-treated rats of 130.77 ± 4.33 (S.E.M.) was significantly (P < 0.001) different to that of 136 neurons in the saline-treated control rats (222.16 ± 6.68), indicating a supersensitivity to adenosine in neurons which had been chronically exposed to caffeine. © 1990.

引用

页码：322 / 323

页数：2

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