ISOLATION AND CHARACTERIZATION OF HEXAKIS(2,6-DI-O-METHYL)CYCLOMALTOHEXAOSE AND OCTAKIS(2,6-DI-O-METHYL)CYCLOMALTO-OCTAOSE, AND THEIR OVER-METHYLATED HOMOLOGS

被引：10
作者：
TANIMOTO, T
KUBOTA, Y
NAKANISHI, N
KOIZUMI, K
机构：
[1] Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 02期
关键词：
6-tri-0-methyl jcyclomaltohex; aose octakisf2.6-di-0-methylcyclomalto-octaose: heDtakisi2.6-di-0-methvn-monof2.3.6-tri-0-methvnc'; hexakis(26-di-0-methyl)cyclomaltohexaose pentakis(26-di-0-methyl)-mono(23; sf- 13C- NMR HPLC FAB-MS solubility; vdnmaltn-nf'tar»;
D O I：
10.1248/cpb.38.318
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The methylation of cyclomaltohexaose (a-CD) and cyclomalto-octaose (y-CD) gave two major components in each case. These methylated compounds were isolated by high-performance liquid chromatography and characterized by carbon-13 nuclear magnetic resonance spectroscopy, fast-atom bombardment mass spectrometry, and fragmentation analysis. The two major products from a-CD were hexakis(2,6-di-0-methyl)cyclomaltohexaose and pentakis(2,6-di-0-methyl)-mono(2,3,6-tri-0-methyl)cyclomaltohexaose and those from y-CD were octakis(2,6-di-0-methyl)cyclomaIto-octaose and heDtakis(2,6-di-0-methvl)-mono(2,3,6-tri-0-methvl)cyclomalto-octaose. © 1990, The Pharmaceutical Society of Japan. All rights reserved.
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页码：318 / 322
页数：5
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