Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature

被引：46

作者：

Goldman, Chloe ^{[1
]}

Akiyama, Matthew J. ^{[1
]}

Torres, Julian ^{[1
]}

Louie, Eddie ^{[1
]}

Meehan, Shane A. ^{[1
]}

机构：

[1] NYU, Med Ctr, 550 First Ave, New York, NY 10016 USA

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2016年 / 11卷

关键词：

Scedosporium; Synergy; GM-CSF; Immunocompromised; Corticosteroid;

D O I：

10.1016/j.mmcr.2016.04.005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents. (C) 2016 The Authors. International Society for Human and Animal Mycology. Published by Elsevier B.V.

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收藏

页码：40 / 43

页数：4

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