AMPHIDINOLIDE-O AND AMPHIDINOLIDE-P, NOVEL 15-MEMBERED MACROLIDES FROM THE DINOFLAGELLATE AMPHIDINIUM SP - ANALYSIS OF THE RELATIVE STEREOCHEMISTRY AND STABLE SOLUTION CONFORMATION

被引：45

作者：

ISHIBASHI, M ^{[1
]}

TAKAHASHI, M ^{[1
]}

KOBAYASHI, J ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 19期

关键词：

D O I：

10.1021/jo00124a015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amphidinolides O (1) and P (2), two novel cytotoxic 15-membered macrolides with unprecedented backbone frameworks, were isolated from the cultured marine dinoflagellate Amphidinium sp. Their gross structures were elucidated by extensive spectroscopic studies, and their relative stereochemistries as well as stable solution conformations were analyzed on the basis of NMR methods and molecular mechanics calculations.

引用

页码：6062 / 6066

页数：5

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