ASCENDING AFFERENT REGULATION OF RAT MIDBRAIN DOPAMINE NEURONS

被引：69

作者：

KELLAND, MD ^{[1
]}

FREEMAN, AS ^{[1
]}

RUBIN, J ^{[1
]}

CHIODO, LA ^{[1
]}

机构：

[1] SINAI RES INST, CTR CELL BIOL, DETROIT, MI 48235 USA

来源：

BRAIN RESEARCH BULLETIN | 1993年 / 31卷 / 05期

关键词：

DORSAL RAPHE NUCLEUS; DPAT; KETAMINE; MESOACCUMBENS DA SYSTEM; NIGROSTRIATAL DA SYSTEM; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; SCIATIC NERVE; SKF; 38393; TFMPP;

D O I：

10.1016/0361-9230(93)90121-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Standard, extracellular single-unit recording techniques were used to examine the electrophysiological and pharmacological responsiveness of midbrain dopamine (DA) neurons to selected, ascending afferent inputs. Sciatic nerve stimulation-induced inhibition of nigrostriatal DA (NSDA) neurons was blocked by both PCPA (5-HT synthesis inhibitor) and 5,7-DHT (5-HT neurotoxin), suggesting mediation by a serotonergic (5-HT) system. Direct stimulation of the dorsal raphe (which utilizes 5-HT as a neurotransmitter and inhibits slowly firing NSDA neurons) inhibited all mesoaccumbens DA (MADA) neurons tested. Paradoxically, DPAT, a 5-HT1A agonist which inhibits 5-HT cell firing, enhanced sciatic nerve stimulation-induced inhibition of NSDA neurons. MADA neurons were not inhibited by sciatic nerve stimulation and, therefore, could not be tested in this paradigm. In contrast to the dorsal raphe, electrical stimulation of the pedunculopontine tegmental nucleus preferentially excited slowly firing NSDA and MADA neurons. Thus, both excitatory and inhibitory ascending afferents influence the activity of midbrain DA neurons, and intact 5-HT systems are necessary for sciatic nerve stimulation to alter DA cell activity. However, the role that 5-HT plays in mediating peripheral sensory input remains unclear.

引用

页码：539 / 546

页数：8

共 59 条

[1]

AGHSAJANIAN GK, 1974, 9 P C COLL INT NEUR, P444

[2]

BENKIRANE S, 1987, N-S ARCH PHARMACOL, V335, P502

[3] SHORT-TERM LITHIUM TREATMENT ENHANCES RESPONSIVENESS OF POSTSYNAPTIC 5-HT1A RECEPTORS WITHOUT ALTERING 5-HT AUTORECEPTOR SENSITIVITY - AN ELECTROPHYSIOLOGICAL STUDY IN THE RAT-BRAIN [J].