PHENOTYPIC PROPERTIES OF LIVER-TUMORS INDUCED BY DEHYDROEPIANDROSTERONE IN F344 RATS

被引：17
作者：
RAO, MS
SUBBARAO, V
KUMAR, S
YELDANDI, AV
REDDY, JK
机构：
[1] Department of Pathology, Northwestern University Medical School, Chicago, Illinois, 60611
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1992年 / 83卷 / 11期
关键词：
HEPATOCELLULAR CARCINOMA; OXIDATIVE STRESS; PEROXISOME; GLUTATHIONE-S-TRANSFERASE-P;
D O I：
10.1111/j.1349-7006.1992.tb02742.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dehydroepiandrosterone (DHEA), a C19 adrenal steroid hormone, induces peroxisome proliferation in liver cells and is hepatocarcinogenic in the rat. The present study deals with the phenotypic properties of DHEA-induced liver lesions. A majority of the altered areas (80 87%), neoplastic nodules (>94%) and hepatocellular carcinomas (HCC, 80-100%) lacked the marker enzymes gamma-glutamyltranspeptidase and placental form of glutathione S-transferase (GSTP). Northern blot analysis of HCC from 4 rats revealed no detectable GSTP mRNA. These HCC, however, showed a marked decrease in the staining of glucose-6-phosphatase and adenosine triphosphatase. These results indicate that the phenotypic properties of liver tumors induced by DHEA and amphipathic carboxylate peroxisome proliferators are similar.
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收藏
页码：1179 / 1183
页数：5
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