CALCIUM AND INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS - A COMPLEX RELATIONSHIP

被引：89
作者：
TAYLOR, CW
MARSHALL, ICB
机构：
[1] Department of Pharmacology, Cambridge, CB2 1QJ, Tennis Court Road
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 10期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0968-0004(92)90009-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increases in intracellular free Ca2+ concentration ([Ca2+]i), whether initiated by changes in plasma membrane potential or receptor-stimulated polyphosphoinositide hydrolysis, can be astonishingly complex, often occurring as repetitive Ca2+ spikes and regenerative Ca2+ Waves that propagate through the cell and sometimes into neighbouring cells. The key to understanding these complex Ca2+ signals lies in understanding the interactions between the different pools from which Ca2+ can rapidly enter the cytosol and the activities of the various Ca2+-transporting systems that reverse the process.
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收藏
页码：403 / 407
页数：5
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