THE MECHANISM OF ACTIVATION OF 4-HYDROXYCYCLOPHOSPHAMIDE

被引：54

作者：

BORCH, RF ^{[1
]}

MILLARD, JA ^{[1
]}

机构：

[1] UNIV ROCHESTER,SCH MED & DENT,CTR CANC,ROCHESTER,NY 14642

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 02期

关键词：

D O I：

10.1021/jm00385a029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：427 / 431

页数：5

共 14 条

[1] INSITU PREPARATION AND FATE OF CIS-4-HYDROXYCYCLOPHOSPHAMIDE AND ALDOPHOSPHAMIDE - H-1 AND P-31 NMR EVIDENCE FOR EQUILIBRATION OF CIS-4--HYDROXYCYCLOPHOSPHAMIDE AND TRANS-4-HYDROXYCYCLOPHOSPHAMIDE WITH ALDOPHOSPHAMIDE AND ITS HYDRATE IN AQUEOUS-SOLUTION [J].

BORCH, RF ;

HOYE, TR ;

SWANSON, TA .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (04) :490-494

[2] BASE-CATALYZED-HYDROLYSIS OF 4-HYDROPEROXYCYCLOPHOSPHAMIDE - EVIDENCE FOR IMINOCYCLOPHOSPHAMIDE AS AN INTERMEDIATE [J].

BORCH, RF ;

GETMAN, KM .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (04) :485-490

[3]

CACECI MS, 1984, BYTE, V9, P340

[4]

FENSELAU C, 1982, DRUG METAB DISPOS, V10, P636

[5]

Friedman O.M., 1979, ADV CANCER CHEMOTHER, V1, P143

[6] SYNTHESIS AND ABSOLUTE-CONFIGURATION OF OPTICALLY-ACTIVE FORMS OF 2-[BIS(2-CHLOROETHYL)AMINO]-4-METHYLTETRAHYDRO-2H-1,3,2-OXAZAPHOSPHORINE 2-OXIDE(4-METHYLCYCLOPHOSPHAMIDE) [J].

KINAS, R ;

PANKIEWICZ, K ;

STEC, WJ ;

FARMER, PB ;

FOSTER, AB ;

JARMAN, M .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (09) :1650-1652

[7]

KOVACH JS, 1984, INVEST NEW DRUG, V2, P155

[8] ACTIVATION MECHANISMS OF MAFOSFAMIDE AND THE ROLE OF THIOLS IN CYCLOPHOSPHAMIDE METABOLISM [J].

KWON, CH ;

BORCH, RF ;

ENGEL, J ;

NIEMEYER, U .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (02) :395-399

[9]

LOW JE, 1983, CANCER RES, V43, P5815

[10]

PETER G, 1976, CANCER TREAT REP, V60, P429

← 1 2 →