EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) ON CATECHOLAMINES AND METABOLITES IN PRIMATE BRAIN AND CSF

被引：96
作者：
ELSWORTH, JD
DEUTCH, AY
REDMOND, DE
SLADEK, JR
ROTH, RH
机构：
[1] YALE UNIV,SCH MED,DEPT PHARMACOL & PSYCHIAT,NEW HAVEN,CT 06510
[2] UNIV ROCHESTER,SCH MED & DENT,ROCHESTER,NY 14642
来源：
BRAIN RESEARCH | 1987年 / 415卷 / 02期
关键词：
D O I：
10.1016/0006-8993(87)90211-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
引用
收藏
页码：293 / 299
页数：7
相关论文
共 25 条
[1]  
ASKARI S, 1986, Society for Neuroscience Abstracts, V12, P83
[2]   3,4-DIHYDROXYPHENYLACETIC ACID AND HOMOVANILLIC-ACID IN RAT PLASMA - POSSIBLE INDICATORS OF CENTRAL DOPAMINERGIC ACTIVITY [J].
BACOPOULOS, NG ;
HATTOX, SE ;
ROTH, RH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 56 (03) :225-236
[3]  
BERNHEIMER H, 1973, J NEUROL SCI, V20, P415, DOI 10.1016/0022-510X(73)90175-5
[4]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[5]   THE CLINICAL SYNDROME OF STRIATAL DOPAMINE DEFICIENCY - PARKINSONISM INDUCED BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].
BURNS, RS ;
LEWITT, PA ;
EBERT, MH ;
PAKKENBERG, H ;
KOPIN, IJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (22) :1418-1421
[6]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[7]   PREFERENTIAL VULNERABILITY OF A8-DOPAMINE NEURONS IN THE PRIMATE TO THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
DEUTCH, AY ;
ELSWORTH, JD ;
GOLDSTEIN, M ;
FUXE, K ;
REDMOND, DE ;
SLADEK, JR ;
ROTH, RH .
NEUROSCIENCE LETTERS, 1986, 68 (01) :51-56
[8]   DIFFERENTIAL RESPONSIVENESS TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE TOXICITY IN SUBREGIONS OF THE PRIMATE SUBSTANTIA-NIGRA AND STRIATUM [J].
ELSWORTH, JD ;
DEUTCH, AY .
LIFE SCIENCES, 1987, 40 (02) :193-202
[9]   PLASMA AND CEREBROSPINAL-FLUID 3-METHOXY-4-HYDROXYPHENYLETHYLENE GLYCOL (MHPG) AS INDEXES OF BRAIN NOREPINEPHRINE METABOLISM IN PRIMATES [J].
ELSWORTH, JD ;
REDMOND, DE ;
ROTH, RH .
BRAIN RESEARCH, 1982, 235 (01) :115-124
[10]   RELATIVE IMPORTANCE OF 3-METHOXY-4-HYDROXYPHENYLGLYCOL AND 3,4-DIHYDROXYPHENYLGLYCOL AS NOREPINEPHRINE METABOLITES IN RAT, MONKEY, AND HUMANS [J].
ELSWORTH, JD ;
ROTH, RH ;
REDMOND, DE .
JOURNAL OF NEUROCHEMISTRY, 1983, 41 (03) :786-793
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