COMBINATION OF THE LIPASE-CATALYZED RESOLUTION WITH THE MITSUNOBU ESTERIFICATION IN ONE-POT

被引：60
作者：
VANTTINEN, E
KANERVA, LT
机构：
[1] Department of Chemistry, University of Turku
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期
关键词：
D O I：
10.1016/0957-4166(95)00224-D
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A chemo-enzymatic method for the preparation of homochiral esters of 14 secondary alcohols with 100% theoretical yields is described in one pot through two steps: the lipase-catalysed kinetic resolution followed by the Mitsunobu esterification of the free alcohol enantiomer in situ in the resolution mixture. Mathematical equations which link the enzymatic and chemical steps were derived, resulting in an enantioconvergent synthetic tool for the preparation of chiral intermediates.
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页码：1779 / 1786
页数：8
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