EFFECTS OF APROTININ ON HEMORRHAGIC COMPLICATIONS IN ARDS PATIENTS DURING PROLONGED EXTRACORPOREAL CO-2 REMOVAL

被引：24
作者：
BRUNET, F
MIRA, JP
BELGHITH, M
LANORE, JJ
SCHLUMBERGER, S
TOULON, P
DHAINAUT, JF
机构：
[1] COCHIN PORT ROYAL UNIV,MED INTENS CARE UNIT,PARIS,FRANCE
[2] FOCH HOSP,CARDIAC SURG UNIT,SURESNES,FRANCE
来源：
INTENSIVE CARE MEDICINE | 1992年 / 18卷 / 06期
关键词：
APROTININ; ADULT RESPIRATORY DISTRESS SYNDROME; EXTRACORPOREAL CO-2 REMOVAL;
D O I：
10.1007/BF01694366
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The effects of aprotinin, a broad-based proteinase inhibitor, in the management of hemorrhagic complications during prolonged venovenous extracorporeal CO2 removal in patients with adult respiratory distress syndrome are not evaluated. In two patients, aprotinin infusion was added to heparin to treat bleeding, occurring after few days of bypass and responsible for respiratory and hemodynamic deterioration. After aprotinin infusion (loading dose of 2 x 10(6) kIU followed by a continuous infusion of 5 x 10(5) kIU/h) combined with heparin, bleeding vanished until the end of bypass.
引用
收藏
页码：364 / 367
页数：4
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