EFFECT OF CALCITONIN ON ACTH-SECRETION

被引：14
|
作者：
RAPISARDA, E [1 ]
CLEMENTI, G [1 ]
FIORE, L [1 ]
PRATO, A [1 ]
CERAVOLO, A [1 ]
RAFFAELE, R [1 ]
SCAPAGNINI, U [1 ]
机构：
[1] UNIV CATANIA, SCH MED, DEPT PHARMACOL & TOXICOL & NEUROL, I-95125 CATANIA, ITALY
来源：
PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1984年 / 16卷 / 12期
关键词：
D O I：
10.1016/S0031-6989(84)80080-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of salmon calcitonin injected intracerebroventricularly on ACTH secretion in rats were investigated. Salmon calcitonin was able to increase significantly (P < 0.05) ACTH secretion at the dose of 5 ng/rat and (P < 0.01) at the doses of 12.5, 25 and 50 ng/rat; the effect (50 ng/rat) was maximal at 30 min and still present after 60 and 120 min. The maximal dose of calcitonin produced a significant (P < 0.05) increase in serum ACTH concentration also in stressed animals. Calcitonin may increase serum ACTH secretion by central norepinephrine and/or 5-hydroxytryptamine pathways that regulate corticotropic releasing factor activity.
引用
收藏
页码：1151 / 1159
页数：9
相关论文
共 50 条
  • [1] DISSOCIATION AND ASSOCIATION BETWEEN CALCITONIN AND ACTH-SECRETION
    LAMBERTS, SWJ
    HACKENG, WHL
    SCHOPMAN, W
    VISSER, TJ
    ACTA ENDOCRINOLOGICA, 1979, 91 : 375 - 375
  • [2] ASSOCIATION AND DISSOCIATION BETWEEN CALCITONIN AND ACTH-SECRETION
    LAMBERTS, SWJ
    HACKENG, WHL
    SCHOPMAN, W
    VISSER, TJ
    CLINICAL RESEARCH, 1979, 27 (02): : A371 - A371
  • [3] EFFECT OF NEUROPEPTIDES ON ACTH-SECRETION IN MAN
    FELBER, JP
    LANCRANJAN, I
    ROUSSELLE, J
    DUBEY, L
    AUDIBERT, A
    HORMONE RESEARCH, 1980, 13 (4-5) : 327 - 327
  • [4] THE EFFECT OF KETOCONAZOLE ON PITUITARY ACTH-SECRETION
    HORWITZ, MJ
    JARRETT, DB
    ROBINSON, AG
    CLINICAL RESEARCH, 1991, 39 (03): : A699 - A699
  • [5] EFFECT OF HYPOTHALAMIC DEAFFERENTATION ON ACTH-SECRETION IN RATS
    SHIMIZU, K
    JAPANESE JOURNAL OF PHARMACOLOGY, 1985, 39 : P365 - P365
  • [6] HYPOTHALAMIC REGULATION OF ACTH-SECRETION
    OLIVER, C
    CONTEDEVOLX, B
    GIRAUD, P
    GILLIOZ, P
    LISSITZKY, JC
    BOUDOURESQUE, F
    HORMONE RESEARCH, 1980, 13 (4-5) : 230 - 241
  • [7] CORTICOSTEROID INHIBITION OF ACTH-SECRETION
    KELLERWOOD, ME
    DALLMAN, MF
    ENDOCRINE REVIEWS, 1984, 5 (01) : 1 - 24
  • [8] STIMULATORY EFFECT OF COCAINE ON ACTH-SECRETION - ROLE OF THE HYPOTHALAMUS
    RIVIER, C
    LEE, S
    MOLECULAR AND CELLULAR NEUROSCIENCE, 1994, 5 (02) : 189 - 195
  • [9] EFFECT OF REPEATED HISTAMINE INJECTIONS ON ACTH-SECRETION IN RATS
    KOYAMA, K
    KIKUCHI, M
    MORITA, Y
    FOLIA PHARMACOLOGICA JAPONICA, 1978, 74 (05) : P81 - P82
  • [10] PHEOCHROMOCYTOMA WITH ECTOPIC ACTH-SECRETION
    GONZALEZVILLARON, L
    SANTANA, S
    PEREZARELLANO, JL
    SANCHEZSANCHEZ, R
    DELPOZO, SC
    REVISTA CLINICA ESPANOLA, 1993, 193 (04): : 168 - 171
12345