2,4-DIFLUOROANILINE AND 4-FLUOROANILINE EXPOSURE - MONITORING BY METHEMOGLOBIN AND URINE ANALYSES

被引：18

作者：

EADSFORTH, CV ^{[1
]}

LOGAN, CJ ^{[1
]}

MORRISON, BJ ^{[1
]}

WARBURTON, PA ^{[1
]}

机构：

[1] SHELL RES LTD, SITTINGBOURNE RES CTR, SITTINGBOURNE ME9 8AG, KENT, ENGLAND

来源：

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | 1984年 / 54卷 / 03期

关键词：

D O I：

10.1007/BF00379051

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Two possible methods for monitoring plant worker exposure to 2,4-difluoroaniline and 4-fluoroaniline were investigated: measurement of methemoglobin content in blood and measurement of urinary metabolites. Experiments using rats dosed by the oral route as a model system showed that measurement of methemoglobin content provided a rapid and simple monitoring method, but was not sensitive. Measurement of the o-hydroxy metabolites of the 2 compounds, as their benzoxazole derivatives, provided a more sensitive, but complicated technique. Details of both methods were presented.

引用

页码：223 / 232

页数：10

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