X=Y-ZN SYSTEMS AS POTENTIAL 1,3-DIPOLES .46. CASCADE 1,3-DIPOLAR CYCLOADDITION REACTIONS OF CEPHALOSPORIN IMINES

被引：16

作者：

GRIGG, R ^{[1
]}

MCMEEKIN, P ^{[1
]}

SRIDHARAN, V ^{[1
]}

机构：

[1] GLAXO RES & DEV,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

TETRAHEDRON | 1995年 / 51卷 / 48期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/0040-4020(95)00847-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Proton sponge effects in ortho-OMe and -NMe(2) arylidene imines of 7-aminocephalosporins promote thermal (toluene, 110 degrees C) 1,2-prototropy to give mixtures of E,E- and E,Z-azomethine ylides which undergo diastereofacially specific (alpha-face) cycloaddition to N-phenylmaleimide to give mixtures of mainly endo-cycloadducts in excellent yield.

引用

收藏

页码：13347 / 13356

页数：10

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