SYNTHESIS OF A BIODEGRADABLE POLYMERIC SUPRAMOLECULAR ASSEMBLY FOR DRUG-DELIVERY

被引：79

作者：

OOYA, T

MORI, H

TERANO, M

YUI, N

机构：

[1] School of Materials Science, Japan Advanced Institute of Science, Tatsunokuchi, 923-12

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 1995年 / 16卷 / 04期

关键词：

D O I：

10.1002/marc.1995.030160405

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel design of a biodegradable carrier for drug delivery was established by constructing a supramolecular assembly of drugs and polymer backbones without any covalent bonds. A biodegradable polyrotaxane was synthesized in which alpha-cyclodextrins (alpha-CDs) as drug carriers were threaded onto poly(ethylene glycol) chains which then were capped at each chain end by L-phenylalanine via peptide linkages. The release of alpha-CDs was observed only when the terminal peptide linkages were degraded.

引用

页码：259 / 263

页数：5

共 13 条

[1]

Baker R., 1987, CONTROLLED RELEASE B

[2] INCLUSION COMPOUNDS .19. FORMATION OF INCLUSION COMPOUNDS OF ALPHA-CYCLODEXTRIN IN AQUEOUS SOLUTIONS . THERMODYNAMICS AND KINETICS [J].