DESIGN AND SYNTHESIS OF A CONFORMATIONALLY CONSTRAINED ANALOG OF THE BIS(HETEROARYL)PIPERAZINE (BHAP) HIV-1 REVERSE-TRANSCRIPTASE INHIBITOR ATEVIRDINE

被引：7

作者：

GENIN, MJ

CHIDESTER, CG

ROHRER, DC

ROMERO, DL

机构：

[1] UPJOHN CO,UPJOHN LABS,MED CHEM RES,KALAMAZOO,MI 49001

[2] UPJOHN CO,UPJOHN LABS,PHYS & ANALYT CHEM,KALAMAZOO,MI 49001

[3] UPJOHN CO,UPJOHN LABS,COMP AIDED DRUG DESIGN,KALAMAZOO,MI 49001

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期

关键词：

D O I：

10.1016/0960-894X(95)00311-G

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design and synthesis of a novel conformationally constrained spiro analog of the BHAP class of HIV-1 reverse transcriptase inhibitors, based on the molecular modeling and the X-ray crystal structure of the clinical candidate atevirdine, is described.

引用

页码：1875 / 1880

页数：6

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