HER-2 NEU-TARGETING GENE-THERAPY - A REVIEW

被引：81

作者：

HUNG, MC ^{[1
]}

MATIN, A ^{[1
]}

ZHANG, YJ ^{[1
]}

XING, XM ^{[1
]}

SORGI, F ^{[1
]}

HUANG, L ^{[1
]}

YU, DH ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT PHARMACOL,PITTSBURGH,PA 15261

来源：

GENE | 1995年 / 159卷 / 01期

关键词：

LIPOSOME; ADENOVIRUS VECTOR; C-ERBB-2; E1A; LARGE T; ONCOGENE;

D O I：

10.1016/0378-1119(94)00459-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The HER-2/neu (also named c-erbB-2) oncogene is known to be overexpressed in many human cancers, including breast, ovarian, lung, gastric and oral cancers. In animal models, HER-2/neu overexpression was shown to enhance malignancy and metastasis phenotypes. Repression of HER-2/neu overexpression suppresses the malignant phenotypes of HER-2/neu-overexpressing cancer cells, suggesting that HER-2/neu may serve as an excellent target for developing anti-cancer agents. We have previously shown that the adenovirus-5 (Ad5) E1a gene products and the SV40 large T antigen (large T) inhibit transcription of the HER-2/neu promoter and accordingly suppresses transformation induced by HER-2/neu. In this review, we summarize our recent findings on using cationic liposomes or an Ad vector to deliver E1a or large T into tumor-bearing mice. Our results indicate that both cationic liposomes or an Ad vector can efficiently deliver E1a or large T into tumor cells in mice, and this results in suppression of tumor growth and longer survival of the mice.

引用

页码：65 / 71

页数：7

共 84 条

[1] INCREASED TYROSINE KINASE-ACTIVITY ASSOCIATED WITH THE PROTEIN ENCODED BY THE ACTIVATED NEU ONCOGENE [J].