MOENOMYCIN-A - STRUCTURE ACTIVITY RELATIONS SYNTHESIS OF THE D-GALACTURONAMIDE ANALOG OF THE SMALLEST ANTIBIOTICALLY ACTIVE DEGRADATION PRODUCT OF MOENOMYCIN-A

被引：24

作者：

MOLLER, U

HOBERT, K

DONNERSTAG, A

WAGNER, P

MULLER, D

FEHLHABER, HW

MARKUS, A

WELZEL, P

机构：

[1] RUHR UNIV BOCHUM,FAK CHEM,POSTFACH 102148,W-4630 BOCHUM,GERMANY

[2] HOECHST AG,PHARMAFORSCH,W-6230 FRANKFURT 80,GERMANY

来源：

TETRAHEDRON | 1993年 / 49卷 / 08期

关键词：

D O I：

10.1016/S0040-4020(01)80351-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compound 10c which is the galacturonamide analogue of 2, the smallest degradation product of moenomycin A (1) with full antibiotic activity, has been synthesized. 10c is devoid of antibiotic activity.

引用

页码：1635 / 1648

页数：14

共 5 条

[1] SYNTHESIS OF 2 STRUCTURAL ANALOGS OF THE SMALLEST ANTIBIOTICALLY ACTIVE DEGRADATION PRODUCT OF MOENOMYCIN-A
HOHGARDT, H
DIETRICH, W
KUHNE, H
MULLER, D
GRZELAK, D
WELZEL, P
TETRAHEDRON, 1988, 44 (18) : 5771 - 5790
[2] MOENOMYCIN-A - A STRUCTURAL REVISION AND NEW STRUCTURE-ACTIVITY RELATIONS
FEHLHABER, HW
GIRG, M
SEIBERT, G
HOBERT, K
WELZEL, P
VANHEIJENOORT, Y
VANHEIJENOORT, J
TETRAHEDRON, 1990, 46 (05) : 1557 - 1568
[3] MOENOMYCIN-A - REACTIONS AT THE LIPID PART - NEW STRUCTURE-ACTIVITY RELATIONS
MARZIAN, S
HAPPEL, M
WAGNER, U
MULLER, D
WELZEL, P
FEHLHABER, HW
STARK, A
SCHUTZ, HJ
MARKUS, A
LIMBERT, M
VANHEIJENOORT, Y
VANHEIJENOORT, J
TETRAHEDRON, 1994, 50 (18) : 5299 - 5308
[4] MOENOMYCIN-A - DEGRADATION OF THE ANTIBIOTIC WITH TRIFLUOROACETIC-ACID - 2-PROPANOL AND THE DETERMINATION OF THE LINKAGE OF D-GLUCOSE AND 2-ACETAMIDO,2-DEOXY D-GLUCOSE
WELZEL, P
KNUPP, G
WITTELER, FJ
SCHUBERT, T
DUDDECK, H
MULLER, D
HOFLE, G
TETRAHEDRON, 1981, 37 (01) : 97 - 104
[5] OPTICALLY-ACTIVE GLYCEROL DERIVATIVES FROM 1,3(R) - 4,6(R)-DI-O-BENZYLIDENE-D-MANNITOL - THE 1ST STRUCTURAL ANALOGS OF MOENOMYCIN-A
SCHUBERT, T
WELZEL, P
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1982, 21 (02): : 137 - 138

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