SHEAR-STRESS INCREASES HEPARIN-BINDING EPIDERMAL GROWTH FACTOR-LIKE GROWTH-FACTOR MESSENGER-RNA LEVELS IN HUMAN VASCULAR ENDOTHELIAL-CELLS

被引：73

作者：

MORITA, T ^{[1
]}

YOSHIZUMI, M ^{[1
]}

KURIHARA, H ^{[1
]}

MAEMURA, K ^{[1
]}

NAGAI, R ^{[1
]}

YAZAKI, Y ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.2469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a recently identified potent vascular smooth muscle cell (SMC) mitogen. we investigated the effect of shear stress on human HB-EGF mRNA levels in cultured human umbilical vein endothelial cells (HUVEC). In response to shear stress (8 dyne/cm2), HB-EGF mRNA levels in HUVEC increased rapidly, peaked at 3 h, and returned to near base line at 7 h. The shear stress-induced HB-EGF gene expression in HUVEC is completely blocked by 12-O-tetra-decanoylphorbol-13-acetate pre-treatment, suggesting the induction of HB-EGF is mediated by protein kinase C. © 1993 Academic Press, Inc.

引用

页码：256 / 262

页数：7

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