IMMUNOHISTOCHEMICAL IDENTIFICATION OF TRANSFORMING GROWTH-FACTOR-BETA AND ITS BINDING-PROTEIN IN HUMAN GASTROINTESTINAL CARCINOMA

被引：4
|
作者：
MIZOI, T [1 ]
OHTANI, H [1 ]
MATSUNO, S [1 ]
NAGURA, H [1 ]
机构：
[1] TOHOKU UNIV, SCH MED, DEPT PATHOL & SURG, SENDAI, MIYAGI 980, JAPAN
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1992年 / 168卷 / 02期
关键词：
TGF-BETA; LATENT TGF-BETA BINDING PROTEIN; GASTROINTESTINAL CARCINOMA; IMMUNOHISTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY;
D O I：
10.1620/tjem.168.271
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We attempted to clarify the tissue localization of TGF-beta and latent TGF-beta binding protein (LTBP) in human gastrointestinal carcinomas by immunohistochemistry. The immunoreactivity for TGF-beta was observed in both carcinoma cells and stromal cells, particularly in diffuse-type gastric carcinoma. The immunoreactivity for LTBP was observed only in stromal cells. These results suggest that both carcinoma cells and stromal cells may produce TGF-beta, and that only stromal cells may produce LTBP in gastrointestinal carcinoma.
引用
收藏
页码：271 / 273
页数：3
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