ARE ESTROGENS INVOLVED IN FALLING SPERM COUNTS AND DISORDERS OF THE MALE REPRODUCTIVE-TRACT

被引：1447

作者：

SHARPE, RM ^{[1
]}

SKAKKEBAEK, NE ^{[1
]}

机构：

[1] UNIV COPENHAGEN,DEPT GROWTH & REPROD,DK-1168 COPENHAGEN,DENMARK

来源：

LANCET | 1993年 / 341卷 / 8857期

关键词：

D O I：

10.1016/0140-6736(93)90953-E

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence of disorders of development of the male reproductive tract has more than doubled in the past 30-50 years while sperm counts have declined by about half. Similar abnormalities occur in the sons of women exposed to diethylstilbestrol (DES) during pregnancy and can be induced in animals by brief exposure to exogenous oestrogen/DES during pregnancy. We argue that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and identify mechanisms by which this exposure could occur.

引用

页码：1392 / 1395

页数：4

共 38 条

[1] DIET, BREAST-CANCER, AND SEX-HORMONE METABOLISM [J].

ADLERCREUTZ, H .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 595 :281-290

[2] LONG-TERM EFFECTS OF PERINATAL EXPOSURE TO SEX STEROIDS AND DIETHYLSTILBESTROL ON THE REPRODUCTIVE-SYSTEM OF MALE MAMMALS [J].

ARAI, Y ;

MORI, T ;

SUZUKI, Y ;

BERN, HA .

INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1983, 84 :235-268

[3] ABNORMAL SEXUAL DEVELOPMENT IN TRANSGENIC MICE CHRONICALLY EXPRESSING MULLERIAN INHIBITING SUBSTANCE [J].

BEHRINGER, RR ;

CATE, RL ;

FROELICK, GJ ;

PALMITER, RD ;

BRINSTER, RL .

NATURE, 1990, 345 (6271) :167-170

[4]

BERNSTEIN L, 1986, J NATL CANCER I, V76, P1035

[5]

BROWN LM, 1992, CANCER RES, V46, P4812

[6] EVIDENCE FOR DECREASING QUALITY OF SEMEN DURING PAST 50 YEARS [J].

CARLSEN, E ;

GIWERCMAN, A ;

KEIDING, N ;

SKAKKEBAEK, NE .

BRITISH MEDICAL JOURNAL, 1992, 305 (6854) :609-613

[7]

Colborn T., 1992, CHEM INDUCED ALTERAT

[8]

COOKE S, 1992, BIOL REPROD, V46, P146

[9] PROLIFERATION OF SERTOLI CELLS DURING DEVELOPMENT OF THE HUMAN TESTIS ASSESSED BY STEREOLOGICAL METHODS [J].

CORTES, D ;

MULLER, J ;

SKAKKEBAEK, NE .

INTERNATIONAL JOURNAL OF ANDROLOGY, 1987, 10 (04) :589-596

[10]

DEGRAAFF WE, 1992, LAB INVEST, V66, P166

← 1 2 3 4 →