ARE ESTROGENS INVOLVED IN FALLING SPERM COUNTS AND DISORDERS OF THE MALE REPRODUCTIVE-TRACT

被引：1446
作者：
SHARPE, RM [1 ]
SKAKKEBAEK, NE [1 ]
机构：
[1] UNIV COPENHAGEN,DEPT GROWTH & REPROD,DK-1168 COPENHAGEN,DENMARK
来源：
LANCET | 1993年 / 341卷 / 8857期
关键词：
D O I：
10.1016/0140-6736(93)90953-E
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The incidence of disorders of development of the male reproductive tract has more than doubled in the past 30-50 years while sperm counts have declined by about half. Similar abnormalities occur in the sons of women exposed to diethylstilbestrol (DES) during pregnancy and can be induced in animals by brief exposure to exogenous oestrogen/DES during pregnancy. We argue that the increasing incidence of reproductive abnormalities in the human male may be related to increased oestrogen exposure in utero, and identify mechanisms by which this exposure could occur.
引用
收藏
页码：1392 / 1395
页数：4
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