It is reported the case of a 39 years old male, non homosexual, seropositive to HIV due to polytransfusion, without AIDS diagnostic criteria and with a severe depression in cellular immunity, expressed as lowering in CD4+ T cells, and in the CD4+/CD8+ ratio, who showed, without having any risk-factors, a squamous cell carcinoma of the tongue. We review the cases reported in the scientific literature on the association between squamous-cell carcinoma and AIDS or HIV infection.