SYNTHESIS, STRUCTURE, ANTIMICROBIAL, AND GENOTOXIC ACTIVITIES OF ORGANOTIN COMPOUNDS WITH 2,6-DIACETYLPYRIDINE NICOTINOYLHYDRAZONES AND ISONICOTINOYLHYDRAZONES

A series of organotin compounds obtained from the reaction of 2,6-diacetylpyridine nicotinoyl-and isonicotinoylhydrazones with tri- and diorganotin chlorides was investigated. The IR and Sn-119 NMR spectroscopic characterization of all the compounds is reported, together with the x-ray crystal structure of [SnEt2(H2dapin')]2[SnEt2Cl3]Cl3.2H2O (H-2dapin' = 2,6-diacetylpyridine bis(isonicotinoylhydrazone)). The main feature in this compound is the presence of a tin atom in both the complex ionic units. The coordination polyhedron is a pentagonal bipyramid in the cation and a trigonal bipyramid in the anion. Results are discussed concerning the in vitro evaluation of antimicrobial properties and genotoxic potential of the compounds described. In all cases the complexes show a reduced antimicrobial activity as compared to that of the corresponding organotin compound. Genotoxic properties of the ligands, detected in the Ames test, disappear in the complexes.