SYNTHESIS OF 13,14-DEHYDROPROSTACYCLIN METHYL-ESTER - POTENT INHIBITOR OF PLATELET-AGGREGATION

被引：61
作者：
FRIED, J
BARTON, J
机构：
[1] UNIV CHICAGO,DEPT CHEM,CHICAGO,IL 60637
[2] UNIV CHICAGO,BEN MAY LAB CANC RES,CHICAGO,IL 60637
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1977年 / 74卷 / 06期
关键词：
D O I：
10.1073/pnas.74.6.2199
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：2199 / 2203
页数：5
相关论文
共 10 条
[1]  
CHAPNICK BM, 1976, J PHARMACOL EXP THER, V196, P44
[2]  
FRIED J, 1976, ADV PROSTAG THROMB R, V1, P183
[3]   SYNTHESIS AND BIOLOGICAL EFFECTS OF 13-DEHYDRO DERIVATIVES OF NATURAL PROSTAGLANDIN-F 2ALPHA AND E2 AND THEIR 15-EPI ENANTIOMERS [J].
FRIED, J ;
LIN, CH .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (04) :429-430
[4]   ARTERIAL-WALLS ARE PROTECTED AGAINST DEPOSITION OF PLATELET THROMBI BY A SUBSTANCE (PROSTAGLANDIN-X) WHICH THEY MAKE FROM PROSTAGLANDIN ENDOPEROXIDES [J].
GRYGLEWSKI, RJ ;
BUNTING, S ;
MONCADA, S ;
FLOWER, RJ ;
VANE, JR .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (05) :685-713
[5]   THROMBOXANES - NEW GROUP OF BIOLOGICALLY-ACTIVE COMPOUNDS DERIVED FROM PROSTAGLANDIN ENDOPEROXIDES [J].
HAMBERG, M ;
SVENSSON, J ;
SAMUELSSON, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) :2994-2998
[6]   CHEMICAL-STRUCTURE OF PROSTAGLANDIN-X (PROSTACYCLIN) [J].
JOHNSON, RA ;
MORTON, DR ;
KINNER, JH ;
GORMAN, RR ;
MCGUIRE, JC ;
SUN, FF ;
WHITTAKER, N ;
BUNTING, S ;
SALMON, J ;
MONCADA, S ;
VANE, JR .
PROSTAGLANDINS, 1976, 12 (06) :915-928
[7]   ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].
MONCADA, S ;
GRYGLEWSKI, R ;
BUNTING, S ;
VANE, JR .
NATURE, 1976, 263 (5579) :663-665
[8]   NOVEL PROSTAGLANDIN DERIVATIVE FORMED FROM ARACHIDONIC ACID BY RAT STOMACH HOMOGENATES [J].
PACEASCIAK, C ;
WOLFE, LS .
BIOCHEMISTRY, 1971, 10 (20) :3657-+
[9]   ISOLATION, STRUCTURE, AND BIOSYNTHESIS OF 6-KETO-PROSTAGLANDIN-F1-ALPHA IN RAT STOMACH [J].
PACEASCIAK, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (08) :2348-2349
[10]  
PACEASCIAK C, 1970, CHEM COMMUN, P1234
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