Execution of RIPK3-regulated necrosis

被引：34
作者：
Cai, Zhenyu
Liu, Zheng-Gang [1 ]
机构：
[1] Ctr Canc Res, Bethesda, MD 20892 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2014年 / 1卷 / 02期
基金：
美国国家卫生研究院;
关键词：
calcium; MLKL; necroptosis; RIP3; ROS; sodium;
D O I：
10.4161/23723548.2014.960759
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis. The newly identified MLKL protein functions downstream of RIP1/RIP3 and is essential for the execution of necroptosis. Studies also indicate involvement of reactive oxygen species and calcium and sodium ions. Identification of the key mediators of necroptosis is critical for understanding the molecular mechanisms of the necroptotic process.
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页数：7
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