ANTIBODIES TO SKELETAL-MUSCLE IN MYASTHENIA-GRAVIS .3. RELATION WITH CLINICAL COURSE AND THERAPY

被引：8
作者：
KUKS, JBM
LIMBURG, PC
HORST, G
OOSTERHUIS, HJGH
机构：
[1] UNIV GRONINGEN HOSP,DEPT RHEUMATOL,9700 RB GRONINGEN,NETHERLANDS
[2] UNIV GRONINGEN HOSP,DEPT CLIN IMMUNOL,9700 RB GRONINGEN,NETHERLANDS
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 1993年 / 120卷 / 02期
关键词：
MYASTHENIA GRAVIS; ANTI-SKELETAL MUSCLE ANTIBODIES; FOLLOW-UP; CLINICAL COURSE; ANTIACETYLCHOLINE RECEPTOR ANTIBODIES; THYMECTOMY; IMMUNOMODULATING DRUGS;
D O I：
10.1016/0022-510X(93)90269-5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fluctuations of anti skeletal muscle antibodies (AMA) were studied in relation to clinical changes and fluctuations in anti acetylcholine receptor antibodies (a-AChR). Forty-two patients with generalized myasthenia gravis were studied in clinical and serological follow-up during several years under various conditions. Results from this study demonstrate that AMA fluctuate in strong relation to a-AChR, clinical course and immunosuppressive therapy. Thymomectomy resulted in an increase or de novo appearance of AMA in 10 of the 12 patients who did not receive immunosuppressive medication.
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页码：168 / 173
页数：6
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