INFLUENCE OF GAS-DENSITY AND PRESSURE ON MICROPARTICLES PRODUCED WITH THE ASES PROCESS

被引：65

作者：

BLEICH, J ^{[1
]}

KLEINEBUDDE, P ^{[1
]}

MULLER, BW ^{[1
]}

机构：

[1] CHRISTIAN ALBRECHTS UNIV KIEL,DEPT PHARMACEUT & BIOPHARMACEUT,D-24118 KIEL,GERMANY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 106卷 / 01期

关键词：

SUPERCRITICAL GAS; SUPERCRITICAL FLUID EXTRACTION; GAS DENSITY; BIODEGRADABLE POLYMER; MICROPARTICLE;

D O I：

10.1016/0378-5173(94)90278-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aerosol solvent extraction system (ASES) uses the extraction properties of supercritical gases to produce microparticles. The extraction properties of the gas depend on pressure, temperature and the adjusted density. As part of a factorial design systematic investigations are carried out on the influence of pressure (in the range of 90-200 bar) and density of the supercritical carbon dioxide (in the range of 0.5-0.8 g/ml) on yield, particle morphology, particle size and release properties of the particles. The results show that the properties of the produced microparticles are hardly influenced by the different production conditions.

引用

页码：77 / 84

页数：8

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