CRUDE EXTRACTS OF HEPATOPROTECTIVE PLANTS, SOLANUM-NIGRUM AND CICHORIUM-INTYBUS INHIBIT FREE RADICAL-MEDIATED DNA-DAMAGE

被引：112

作者：

SULTANA, S ^{[1
]}

PERWAIZ, S ^{[1
]}

IQBAL, M ^{[1
]}

ATHAR, M ^{[1
]}

机构：

[1] JAMIA HAMDARD,DEPT MED ELEMENTOL & TOXICOL,NEW DELHI 110062,INDIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 45卷 / 03期

关键词：

HEPATOPROTECTIVE PLANTS; FREE RADICALS; DNA DAMAGE;

D O I：

10.1016/0378-8741(94)01214-K

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The presence of plant extracts of Solanum nigrum and Cichorium intybus in the reaction mixture containing calf thymus DNA and free radical generating system protect DNA against oxidative damage to its deoxyribose sugar moiety. The effect was dependent on the concentration of plant extracts. However, the effect of Cichorium intybus was much pronounced as compared to the effect of Solanum nigrum. These studies suggest that the observed hepatoprotective effect of these crude plant extracts may be due to their ability to suppress the oxidative degradation of DNA in the tissue debris.

引用

页码：189 / 192

页数：4

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