HYPERSENSITIVITY OF LEC STRAIN RATS IN RADIATION-INDUCED ACUTE BONE-MARROW DEATH

被引：20
作者：
HAYASHI, M
ENDOH, D
KON, Y
YAMASHITA, T
SATO, F
KASAI, N
NAMIOKA, S
机构：
[1] HOKKAIDO UNIV,DEPT RADIAT BIOL,SAPPORO,HOKKAIDO 060,JAPAN
[2] HOKKAIDO UNIV,FAC VET MED,DEPT VET ANAT,SAPPORO,HOKKAIDO 060,JAPAN
[3] HOKKAIDO UNIV,INST ANIM EXPERIMENTAT,SAPPORO,HOKKAIDO 060,JAPAN
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 1993年 / 55卷 / 01期
关键词：
ACUTE BONE-MARROW DEATH; HYPERSENSITIVITY; LD50/30; LEC STRAIN RAT; RADIATION DEATH;
D O I：
10.1292/jvms.55.13
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
LEC strain rats, which have been known to develop hereditarily spontaneous fulminant hepatitis 4 to 5 months after birth, were highly sensitive to whole-body X ray-irradiation as compared to WKAH strain rats. Radiation-induced acute bone-marrow death occurred at doses higher than 2.0 Gy in LEC rats, and at doses higher than 7.4 Gy in WKAH rats, respectively. By probit analysis of survival data, it was shown that the LD50/30 value for LEC rats was 3.0 Gy which was significantly lower than that (7.8 Gy) of WKAH rats. Histopathological examinations of the bone marrows from both strains after irradiation at a dose of 4.0 Gy revealed that a number of hemopoietic cells were recovered in WKAH rats on day 8 after irradiation, but not in LEC rats. These results suggested the hypersensitivity of LEC rats to ionizing radiation in connection with acute bone-marrow death.
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页码：13 / 18
页数：6
相关论文
共 25 条
[1]   SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING-RADIATION AND A DEFICIENCY IN DNA DOUBLE-STRAND BREAK REPAIR [J].
BIEDERMANN, KA ;
SUN, JR ;
GIACCIA, AJ ;
TOSTO, LM ;
BROWN, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1394-1397
[2]   ATTACK OF FREE RADICALS ON BIOLOGICALLY ACTIVE DNA IN IRRADIATED AQUEOUS SOLUTIONS [J].
BLOK, J ;
VERHEY, WSD .
RADIATION RESEARCH, 1968, 34 (03) :689-&
[3]  
Bond VP, 1965, MAMMALIAN RAD LETHAL, P159
[4]   RECOVERY FROM PARTIAL-BODY X-IRRADIATION AS MEASURED BY THE LETHALITY OF 2 EXPOSURES [J].
CARSTEN, AL ;
NOONAN, TR .
RADIATION RESEARCH, 1959, 11 (02) :165-176
[5]   THE COPPER AND IRON CONTENT OF BRAIN AND LIVER IN THE NORMAL AND IN HEPATO-LENTICULAR DEGENERATION [J].
CUMINGS, JN .
BRAIN, 1948, 71 (04) :410-415
[6]  
FLIEDNER TM, 1961, AM J PATHOL, V38, P599
[7]  
FLIEDNER TM, 1955, STRAHLENTHERAPIE, V101, P308
[8]   HIGHER SENSITIVITY OF LEC STRAIN RAT IN RADIATION-INDUCED ACUTE INTESTINAL DEATH [J].
HAYASHI, M ;
ENDOH, D ;
KON, Y ;
YAMASHITA, T ;
HASHIMOTO, N ;
SATO, F ;
KASAI, N ;
NAMIOKA, S .
JOURNAL OF VETERINARY MEDICAL SCIENCE, 1992, 54 (02) :269-273
[9]   DIURNAL-VARIATIONS IN RADIOSENSITIVITY OF MOUSE INTESTINE [J].
HENDRY, JH .
BRITISH JOURNAL OF RADIOLOGY, 1975, 48 (568) :312-314
[10]  
HURSCH JB, 1954, BRIT J RADIOL, V29, P169
123