ADENOSINE DEPRESSES INDUCTION OF LTP AT THE MOSSY FIBER-CA3 SYNAPSE INVITRO

被引：32

作者：

ALZHEIMER, C ^{[1
]}

ROHRENBECK, J ^{[1
]}

TENBRUGGENCATE, G ^{[1
]}

机构：

[1] UNIV MUNICH,DEPT PHYSIOL,W-8000 MUNICH 2,GERMANY

来源：

BRAIN RESEARCH | 1991年 / 543卷 / 01期

关键词：

HIPPOCAMPAL SLICE; FIELD EXCITATORY POSTSYNAPTIC POTENTIAL; MOSSY FIBER-CA3 SYNAPSE; LONG-TERM POTENTIATION; ADENOSINE; NEUROMODULATION;

D O I：

10.1016/0006-8993(91)91061-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50-mu-M) significantly suppressed mossy fiber LTP whereas it failed to inhibit LTP when applied immediately after high-frequency stimulation. Based on the hypothesis that mossy fiber LTP is presynaptic in origin, our data thus provide first evidence that adenosine's presynaptic action alone is sufficiently powerful to interfere with synaptic plasticity.

引用

页码：163 / 165

页数：3

共 11 条

[1] TRANSIENT AND SELECTIVE BLOCKADE OF ADENOSINE A1-RECEPTORS BY 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE (DPCPX) CAUSES SUSTAINED EPILEPTIFORM ACTIVITY IN HIPPOCAMPAL CA3 NEURONS OF GUINEA-PIGS [J].