COPPER COMPLEXES OF AMINOTHIOPHENE SCHIFF BASES AS ANTIMICROBIAL AGENTS: SYNTHESIS, STRUCTURAL CHARACTERIZATION, ANTIMICROBIAL AND ANTITUBERCULAR ACTIVITY EVALUATION

被引：0
作者：
More, Ganesh [1 ]
Bootwala, Sakina [1 ]
Patil, Sujata [2 ]
机构：
[1] Wilson Coll, Dept Chem, Bombay 400007, Maharashtra, India
[2] Wilson Coll, Dept Phys, Bombay 400007, Maharashtra, India
来源：
HETEROCYCLIC LETTERS | 2018年 / 8卷 / 02期
关键词：
Copper complex; Uropathogens; Multidrug-resistant; Schiff bases; H37Rv;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Series of potentially tridentate Schiff bases (3a-d) were derived from condensation of ethyl 2-amino-5,6-dihydro-4H-cyclopenta[b] thiophene-3-carboxylate (I) with o-hydroxyl aldehyde derivative (2a-d) which formed Cu(II) complexes in 1: 1 molar ratio. All the complexes were characterized by elemental analysis, FTIR, UV-Visible and ESR spectroscopy, XRD, magnetic susceptibility and molar conductance technique. According to spectroscopic and magnetic moment data, the monobasic tridentate ligand forms square planar complexes with Cu(II) metal ions. Metal complexes exhibited pronounced activity against gram-negative ESBL and MBL bacterial strains compared to the ligands. In addition, metal complexes displayed good antitubercular activity against M. tuberculosis (H37Rv strain).
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页码：345 / 357
页数：13
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