INFLUENCE OF SOME DOPAMINERGIC AGENTS ON ANTINOCICEPTION PRODUCED BY QUININE IN MICE

被引：1
作者：
AMABEOKU, G [1 ]
EWESUEDO, R [1 ]
ABUH, F [1 ]
机构：
[1] AHMADU BELLO UNIV, FAC PHARMACEUT SCI, DEPT PHARMACOL & CLIN PHARMACOL, ZARIA, NIGERIA
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1992年 / 16卷 / 03期
关键词：
ANTINOCICEPTION; DOPAMINERGIC MECHANISM; MICE; QUININE; TAIL-IMMERSION TEST;
D O I：
10.1016/0278-5846(92)90086-T
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. The analgesic effect of quinine and the influence of some dopaminergic agents on it were studied in mice. 2. Quinine (25-130mg/kg, ip) effectively elicited antinociceptive effect in a dose related manner. 3. D-Amphetamine (2.5-4mg/kg, ip), L-dopa (25mg/kg, sc), L-dopa (25mg/kg, sc) plus benserazide (12.5mg/kg, sc), alpha-methyl-p-tyrosine (50mg/kg, ip) plus L-dopa (25mg/kg, sc) and pargyline (50mg/kg, ip) significantly attenuated the antinociceptive effect of quinine (50mg/kg, ip), while DOPS (4mg/kg, ip) did not affect quinine antinociception. 4. Pimozide (4mg/kg, ip), L-sulpiride (40mg/kg, ip), SCH 23390 (0.2mg/kg, sc) and alpha-methyl-p-tyrosine (50mg/kg, ip) effectively potentiated the antinociceptive effects of quinine (50mg/kg, ip). 5. Pimozide (4mg/kg, ip) also antagonised the antagonistic effect of d-amphetamine (4mg/kg, ip) on the antinociceptive effect of quinine (50mg/kg, ip). 6. These data indicate that quinine elicited antinociception dose dependently. Furthermore, the influence of pimozide, L-sulpiride and SCH 23390 on quinine antinociception suggests the involvement of dopaminergic mechanisms.
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页码：351 / 360
页数：10
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