ROLE OF FATTY-ACIDS AND EICOSANOIDS IN MODULATING PROTEOGLYCAN METABOLISM IN ENDOTHELIAL-CELLS

被引:16
作者
HENNIG, B
LIPKE, DW
BOISSONNEAULT, GA
RAMASAMY, S
机构
[1] UNIV KENTUCKY, COLL PHARM, LEXINGTON, KY 40506 USA
[2] UNIV KENTUCKY, DEPT CLIN SCI, LEXINGTON, KY 40506 USA
来源
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1995年 / 53卷 / 05期
关键词
D O I
10.1016/0952-3278(95)90050-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Endothelial cell dysfunction is considered to be a critical event in the etiology of atherosclerosis, Thus, the preservation of endothelial structure and function are a prerequisite for normal control of vascular permeability properties, mediation of both inflammatory and immunologic responses and the general 'communication' between blood-borne cells and abluminal tissues, Many of these properties can be influenced by proteoglycans present in vascular tissues, There is evidence that selected lipids can be atherogenic by altering endothelial proteoglycan metabolism, Little is known about the role of fatty acids in modulating proteoglycan composition in endothelial cells, Data suggest, however, that linoleic acid in particular can adversely alter proteoglycan metabolism, which may be related to an imbalance in eicosanoid synthesis patterns, These events could be sufficient to disrupt normal endothelial barrier function, initiate smooth muscle migration and proliferation, and result in other metabolic dysfunctions associated with the etiology of vascular diseases such as atherosclerosis, Thus, the focus of this review is on fatty acids and eicosanoids as they may alter proteoglycan metabolism of vascular tissues and in particular of the endothelium.
引用
收藏
页码:315 / 324
页数:10
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