BLOOD-PRESSURE AND PHARMACOKINETICS IN COMBINATION THERAPY WITH CYCLOSPORINE AND NITRENDIPINE

被引:0
|
作者
BRUCKNER, D
HOHAGE, H
GELLERT, J
RAHN, KH
机构
关键词
NITRENDIPINE; CYCLOSPORINE; PHARMACOKINETICS; BLOOD PRESSURE;
D O I
暂无
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Effects of nitrendipine on hemodynamics and on ciclosporine pharmacokinetics were studied in 6 patients with terminal renal failure. Kinetic parameters were calculated after a single oral dose of 20 mg nitrendipine, a single oral dose of 120 mg ciclosporine and after concomitant therapy. Steady-state blood levels were determined after a 6 days' oral treatment with 20 mg nitrendipine twice daily or 120 mg ciclosporine twice daily or after concomitant therapy. Blood pressure was measured before the blood samples for the concentration-time curves were collected and compared with the blood pressure during the last four weeks before treatment. The concomitant therapy shortened the t(max), for ciclosporine this effect was significant (1.6 h versus 2.4 h; p <0,05). The AUC and the C(max) of both drugs did not change statistically significant. At the time of C(max) for ciclosporine, the blood pressure was significantly higher than before treatment (158/93 versus 149/83 mmHg; p <0.05). The simultaneous administration of nitrendipine was able to compensate for this effect.
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页码:208 / 209
页数:2
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