CHEMICAL AND MICROBIOLOGICAL INVESTIGATIONS OF METAL-ION INTERACTION WITH NORFLOXACIN

被引：36
作者：
ALKAYSI, HN
ABDELHAY, MH
SALEM, MS
GHARAIBEH, AM
NAWAS, TE
机构：
[1] JORDAN UNIV SCI & TECHNOL,FAC MED,IRBID,JORDAN
[2] UNIV ALEXANDRIA,FAC PHARM,ALEXANDRIA,EGYPT
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 87卷 / 1-3期
关键词：
NORFLOXACIN; NORFLOXACIN-METAL ION INTERACTION; ANTIMICROBIAL ACTIVITY; SPECTROPHOTOMETRY;
D O I：
10.1016/0378-5173(92)90229-U
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffeTS of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar ratio methods. The ratios were NFX: Al3+, 2:1 and 3:1 for the NFX: Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions.
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页码：73 / 77
页数：5
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