MLS - A RETROVIRUS EXPLOITS THE IMMUNE-SYSTEM

被引：240
作者：
ACHAORBEA, H [1 ]
PALMER, E [1 ]
机构：
[1] UNIV COLORADO, HLTH SCI CTR,NATL JEWISH CTR IMMUNOL & RESP MED, DEPT PEDIAT,DIV BASIC SCI, DENVER, CO 80206 USA
来源：
IMMUNOLOGY TODAY | 1991年 / 12卷 / 10期
关键词：
D O I：
10.1016/0167-5699(91)90066-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The identity of minor lymphocyte stimulating (Mls) antigens, endogenous superantigens that can activate, or induce the deletion of, large portions of the T-cell repertoire, has recently been revealed: they are encoded by mouse mammary tumor viruses (MMTV) that have integrated into the germ line as DNA proviruses. As Hans Acha-Orbea and Ed Palmer point out, Mls-mediated modulation may be only the tip of the retrovirus iceberg; already murine leukemia virus (MuLV), with similar superantigen properties, has been discovered.
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页码：356 / 361
页数：6
相关论文
共 66 条
[1]  
ABE R, 1989, ANNU REV IMMUNOL, V7, P683, DOI 10.1146/annurev.iy.07.040189.003343
[2]   CLONAL DELETION OF V-BETA 14-BEARING T-CELLS IN MICE TRANSGENIC FOR MAMMARY-TUMOR VIRUS [J].
ACHAORBEA, H ;
SHAKHOV, AN ;
SCARPELLINO, L ;
KOLB, E ;
MULLER, V ;
VESSAZSHAW, A ;
FUCHS, R ;
BLOCHLINGER, K ;
ROLLINI, P ;
BILLOTTE, J ;
SARAFIDOU, M ;
MACDONALD, HR ;
DIGGELMANN, H .
NATURE, 1991, 350 (6315) :207-211
[3]   EXPRESSION OF M LOCUS DIFFERENCES BY B CELLS BUT NOT T-CELLS [J].
BOEHMER, HV ;
SPRENT, J .
NATURE, 1974, 249 (5455) :363-365
[4]   SPECIFIC RECEPTOR-BINDING OF STAPHYLOCOCCAL ENTEROTOXINS BY MURINE SPLENIC LYMPHOCYTES [J].
BUXSER, S ;
BONVENTRE, PF ;
ARCHER, DL .
INFECTION AND IMMUNITY, 1981, 33 (03) :827-833
[5]   V-BETA-17 GENE POLYMORPHISM IN WILD-DERIVED MOUSE STRAINS - 2 AMINO-ACID SUBSTITUTIONS IN THE V-BETA-17 REGION GREATLY ALTER T-CELL RECEPTOR SPECIFICITY [J].
CAZENAVE, PA ;
MARCHE, PN ;
JOUVINMARCHE, E ;
VOEGTLE, D ;
BONHOMME, F ;
BANDEIRA, A ;
COUTINHO, A .
CELL, 1990, 63 (04) :717-728
[6]   A SUPERANTIGEN ENCODED IN THE OPEN READING FRAME OF THE 3' LONG TERMINAL REPEAT OF MOUSE MAMMARY-TUMOR VIRUS [J].
CHOI, YW ;
KAPPLER, JW ;
MARRACK, P .
NATURE, 1991, 350 (6315) :203-207
[7]   CHRONIC ARTHRITIS IN GOATS CAUSED BY A RETROVIRUS [J].
CRAWFORD, TB ;
ADAMS, DS ;
CHEEVERS, WP .
SCIENCE, 1980, 207 (4434) :997-999
[8]   MOLECULAR-CLONING AND SEQUENCING OF THE MTV-1 LTR - EVIDENCE FOR A LTR SEQUENCE ALTERATION [J].
CROUSE, CA ;
PAULEY, RJ .
VIRUS RESEARCH, 1989, 12 (02) :123-138
[9]  
DEKRUYFF RH, 1986, J IMMUNOL, V137, P1109
[10]   SUPERANTIGENS INTERACT WITH MHC CLASS-II MOLECULES OUTSIDE OF THE ANTIGEN GROOVE [J].
DELLABONA, P ;
PECCOUD, J ;
KAPPLER, J ;
MARRACK, P ;
BENOIST, C ;
MATHIS, D .
CELL, 1990, 62 (06) :1115-1121
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