Toxicity of iron and hydrogen peroxide: The Fenton reaction

被引：1029
作者：
Winterbourn, CC
机构：
[1] Department of Pathology, Christchurch School of Medicine, Christchurch
来源：
TOXICOLOGY LETTERS | 1995年 / 82-3卷
关键词：
iron mediated injury; Fenton reaction; hydroxyl radical toxicity;
D O I：
10.1016/0378-4274(95)03532-X
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Iron and hydrogen peroxide are capable of oxidizing a wide range of substrates and causing biological damage. The reaction, referred to as the Fenton reaction, is complex and capable of generating both hydroxyl radicals and higher oxidation states of the iron. The mechanism and how it is affected by different chelators, and the interpretation of results obtained in biological systems, are discussed.
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页码：969 / 974
页数：6
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