REACTION OF NITRIC-OXIDE AND ITS DERIVATIVES WITH SULFITES - A POSSIBLE ROLE IN SULFITE TOXICITY

被引：11

作者：

HARVEY, SB ^{[1
]}

NELSESTUEN, GL ^{[1
]}

机构：

[1] UNIV MINNESOTA, DEPT BIOCHEM, ST PAUL, MN 55108 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1995年 / 1267卷 / 01期

关键词：

NITRIC OXIDE; NITRIC OXIDE DERIVATIVE; SULFITE TOXICITY; PLATELET AGGREGATION; SIGNALING; RESPIRATORY DISEASE;

D O I：

10.1016/0167-4889(95)00059-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction between sulfites and nitric oxide or proposed carriers of nitric oxide (nitrosylated bovine serum albumin and S-nitrosoglutathione) was investigated as a potential source of the adverse effects of sulfites on biological systems. Rapid reaction occurred between sulfites and all of these reagents. Also, the ability of nitric oxide and these carriers of nitric oxide to inhibit platelet aggregation was reversed by low concentrations of sulfites. Counteraction of nitric oxide's ability to function in cell signaling processes may be a major cause of sulfite toxicity.

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页码：41 / 44

页数：4

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