ACYLOXYMETHYL AS AN ACTIVATING GROUP IN LIPASE-CATALYZED ENANTIOSELECTIVE HYDROLYSIS - A VERSATILE APPROACH TO CHIRAL 4-ARYL-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATES

被引：56

作者：

EBIIKE, H ^{[1
]}

TERAO, Y ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, 395 YADA, OYA, SHIZUOKA 422, JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 41期

关键词：

1,4-DIHYDROPYRIDINE; LIPASE; ENANTIOSELECTIVE HYDROLYSIS; ACYLOXYMETHYLESTER; CALCIUM ANTAGONIST;

D O I：

10.1016/S0040-4039(00)93560-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first practical syntheses of chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates, which are attractive compounds as new calcium antagonists, were realized by lipase-catalyzed enantioselective hydrolysis of the acyloxymethyl esters. The monoesters obtained were revealed to have high optical purity and demonstrated to be useful chiral synthons.

引用

页码：5805 / 5808

页数：4

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