ASSIGNMENT OF THE ABSOLUTE-CONFIGURATION TO WINTERSTEIN ACID, R-3-DIMETHYLAMINO-3-PHENYL PROPIONIC-ACID, BY THE ASYMMETRIC-SYNTHESIS OF HOMOCHIRAL (S)-(+)-ETHYL 3-DIMETHYLAMINO-3-PHENYL PROPIONATE

被引：20

作者：

DAVIES, SG

DUPONT, J

EASTON, RJC

机构：

[1] The Dyson Perrins Laboratory, Oxford, OX1 3QY, South Park Road

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(00)86312-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The asymmetric synthesis of homochiral (S)-(+)-ethyl 3-dimethylamino-3-phenyl propionate, via stereoselective Michael addition of lithium dimethylamide to (S)-Z-[(η5-C5H5)-Fe(CO)(PPh3)COCHCHPh] and oxidative decomplexation, establishes the absolute configuration of Winterstein's acid, 3-dimethylamino-3-phenyl propionic acid, derived from Taxine B, as R. © 1990.

引用

页码：279 / 280

页数：2

共 7 条

[1] SYNTHESIS AND CHARACTERIZATION OF E-ALPHA,BETA-UNSATURATED AND Z-ALPHA,BETA-UNSATURATED ACYL COMPLEXES [(ETA-5-C5H5)FE(CO)(PPH3)(COCH=CHR)](R=H,ME,ET,NORMAL-BU,TERT-BU,PH,VINYL,2-FURYL) [J].