CATECHOLAMINE-INDUCED CARDIOMYOPATHY IN MULTIPLE ENDOCRINE NEOPLASIA - A HISTOLOGIC, ULTRASTRUCTURAL, AND BIOCHEMICAL-STUDY

被引：70
作者：
FRUSTACI, A
LOPERFIDO, F
GENTILONI, N
CALDARULO, M
MORGANTE, E
RUSSO, MA
机构：
[1] UNIV ROME LA SAPIENZA, DEPT EXPTL MED, I-00185 ROME, ITALY
[2] UNIV CATTOLICA SACRO CUORE, INST CARDIOL & INTERNAL MED, I-00168 ROME, ITALY
来源：
CHEST | 1991年 / 99卷 / 02期
关键词：
D O I：
10.1378/chest.99.2.382
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A catecholamine-induced dilated cardiomyopathy is reported in a patient with multiple endocrine neoplasia, type 3. A histologic and ultrastructural study has been undertaken in cardiac biopsy samples, together with determination of myocardial Ca++ and cellular membrane fatty acids. Contraction band necrosis of cardiocytes with supercontraction of sarcomeres progressing to myofibrolysis and increased levels of myocardial Ca++ have been found as morphologic and biochemical abnormalities, respectively. No lipoperoxidation of cellular membranes or an alpha-adrenergic mediated reduction of coronary supply could be recognized in the study. We indicate a receptor-mediated intracellular Ca++ overload as the main abnormality responsible for myocardial impairment.
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页码：382 / 385
页数：4
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