RENAL TUBULAR DYSFUNCTION IN FETAL ALCOHOL SYNDROME

被引：24
作者：
ASSADI, FK
机构：
[1] Department of Pediatrics, Division of Nephrology, 1245 CSB, M/C 856, University of Illinois College of Medicine, Chicago, 60612, IL
来源：
PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 01期
关键词：
Fetal alcohol syndrome; Renal tubular dysfunction; Urine acidification; Urine concentration;
D O I：
10.1007/BF00858439
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Renal function was evaluated in six patients with fetal alcohol syndrome (FAS) and eight control subjects before and after fluid restriction and acute acid loading. Baseline serum electrolytes, creatinine clearance, fractional sodium excretion, tubular reabsorption of phosphate, urine and blood pH and osmolalities, plasma renin activity, and plasma aldosterone level were normal in all subjects, but fractional potassium excretion (FEK) was lower in FAS patients than in control subjects (P<0.001). Despita equivalent plasma osmolalities (295±3 vs 293±2 mosmol/kg, P=0.2), the maximum urinary osmolality after 12 h of water deprivation in patients with FAS was significantly lower compared with controls (560±107 vs 965±77 mosmol/kg;P<0.001) and increased to only 578±101 mosmol/kg after vasopressin administration. After ammonium chloride loading, minimum urine pH was significantly higher in patients than in controls (5.7±0.17 vs 4.81±0.19;P<0.001). Net acid excretion and FEK were also lower in patients than in controls (102±11 vs 139.6±11.3 μEq/min per 1.73 m2 and 23.5±1.3 vs 29±1.6%, respectively;P<0.001). The data indicate a subclinical renal tubular defect in urine concentration and acidification in patients with FAS. © 1990 IPNA.
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页码：48 / 51
页数：4
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