Cutaneous Squamous Cell Carcinoma Developing from Recessive Dystrophic Epidermolysis Bullosa: A Case Report and an Immunohistochemical Study

被引：5
|
作者：
Tsukada, Akira [1 ]
Fujimura, Taku [1 ]
Furudate, Sadanori [1 ]
Kambayashi, Yumi [1 ]
Numata, Yukikazu [1 ]
Haga, Takahiro [1 ]
Hashimoto, Akira [1 ]
Aiba, Setsuya [1 ]
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi, Japan
来源：
CASE REPORTS IN DERMATOLOGY | 2012年 / 4卷 / 03期
关键词：
Recessive dystrophic epidermolysis bullosa; Squamous cell carcinoma; Immunosuppressive cells; Carcinogenesis;
D O I：
10.1159/000343082
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We describe a 49-year-old Japanese woman with cutaneous squamous cell carcinoma (SCC) developing from recessive dystrophic epidermolysis bullosa (RDEB). Interestingly, immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages and numerous Foxp3(+) regulatory T cells (Tregs) around the tumor. Since the contribution of immunosuppressive factors (e.g. TGF beta) to the carcinogenesis of SCC from RDEB was recently reported, our present findings suggest one of the possible contributions of immunosuppressive cells, such as CD163(+) M2 macrophages and Tregs, to the carcinogenesis of SCC from RDEB.
引用
收藏
页码：197 / 201
页数：5
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