MICROBIAL ASYMMETRIC DECARBOXYLATION OF FLUORINE-CONTAINING ARYLMALONIC ACID-DERIVATIVES

被引：22
作者：
MIYAMOTO, K
TSUCHIYA, S
OHTA, H
机构：
[1] Department of Chemistry, Keio University, Kohoku-ku, Yokohama, 225
来源：
JOURNAL OF FLUORINE CHEMISTRY | 1992年 / 59卷 / 02期
关键词：
D O I：
10.1016/S0022-1139(00)82414-8
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Alpha-Methyl-alpha-(trifluoromethylphenyl)malonic acids have been incubated with Alcaligenes bronchisepticus to afford optically active alpha-arylpropionic acids. Generally, the chemical and optical yields of the reaction products were higher when the substituents on the aromatic ring were strongly electron-withdrawing. Decarboxylation of alpha-fluoro-alpha-phenylmalonic acid with the aid of the same bacterium afforded optically active alpha-fluoro-alpha-phenylacetic acid.
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页码：225 / 232
页数：8
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