INTRODUCTION OF A MU-IMMUNOGLOBULIN GENE INTO THE MOUSE GERM LINE - SPECIFIC EXPRESSION IN LYMPHOID-CELLS AND SYNTHESIS OF FUNCTIONAL ANTIBODY

被引:283
作者
GROSSCHEDL, R
WEAVER, D
BALTIMORE, D
COSTANTINI, F
机构
[1] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
[2] MIT,CTR CANC RES,CAMBRIDGE,MA 02139
[3] COLUMBIA UNIV COLL PHYS & SURG,DEPT HUMAN GENET & DEV,NEW YORK,NY 10032
关键词
D O I
10.1016/0092-8674(84)90259-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:647 / 658
页数:12
相关论文
共 54 条
[1]   ORGANIZATION AND REORGANIZATION OF IMMUNOGLOBULIN GENES IN A-MULV TRANSFORMED-CELLS - REARRANGEMENT OF HEAVY BUT NOT LIGHT CHAIN GENES [J].
ALT, F ;
ROSENBERG, N ;
LEWIS, S ;
THOMAS, E ;
BALTIMORE, D .
CELL, 1981, 27 (02) :381-390
[2]   SYNTHESIS OF SECRETED AND MEMBRANE-BOUND IMMUNOGLOBULIN-MU HEAVY-CHAINS IS DIRECTED BY MESSENGER-RNAS THAT DIFFER AT THEIR 3' ENDS [J].
ALT, FW ;
BOTHWELL, ALM ;
KNAPP, M ;
SIDEN, E ;
MATHER, E ;
KOSHLAND, M ;
BALTIMORE, D .
CELL, 1980, 20 (02) :293-301
[3]   ACTIVITY OF MULTIPLE LIGHT CHAIN GENES IN MURINE MYELOMA CELLS PRODUCING A SINGLE, FUNCTIONAL LIGHT CHAIN [J].
ALT, FW ;
ENEA, V ;
BOTHWELL, ALM ;
BALTIMORE, D .
CELL, 1980, 21 (01) :1-12
[4]  
ALT FW, 1982, MOL CELL BIOL, V2, P286
[5]   METHOD FOR DETECTION OF SPECIFIC RNAS IN AGAROSE GELS BY TRANSFER TO DIAZOBENZYLOXYMETHYL-PAPER AND HYBRIDIZATION WITH DNA PROBES [J].
ALWINE, JC ;
KEMP, DJ ;
STARK, GR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5350-5354
[6]   A LYMPHOCYTE-SPECIFIC CELLULAR ENHANCER IS LOCATED DOWNSTREAM OF THE JOINING REGION IN IMMUNOGLOBULIN HEAVY-CHAIN GENES [J].
BANERJI, J ;
OLSON, L ;
SCHAFFNER, W .
CELL, 1983, 33 (03) :729-740
[7]   HEAVY-CHAIN VARIABLE REGION CONTRIBUTION TO THE NPB FAMILY OF ANTIBODIES - SOMATIC MUTATION EVIDENT IN A GAMMA-2A VARIABLE REGION [J].
BOTHWELL, ALM ;
PASKIND, M ;
RETH, M ;
IMANISHIKARI, T ;
RAJEWSKY, K ;
BALTIMORE, D .
CELL, 1981, 24 (03) :625-637
[8]   SOMATIC EXPRESSION OF HERPES THYMIDINE KINASE IN MICE FOLLOWING INJECTION OF A FUSION GENE INTO EGGS [J].
BRINSTER, RL ;
CHEN, HY ;
TRUMBAUER, M ;
SENEAR, AW ;
WARREN, R ;
PALMITER, RD .
CELL, 1981, 27 (01) :223-231
[9]   EXPRESSION OF A MICROINJECTED IMMUNOGLOBULIN GENE IN THE SPLEEN OF TRANSGENIC MICE [J].
BRINSTER, RL ;
RITCHIE, KA ;
HAMMER, RE ;
OBRIEN, RL ;
ARP, B ;
STORB, U .
NATURE, 1983, 306 (5941) :332-336
[10]   ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].
CHIRGWIN, JM ;
PRZYBYLA, AE ;
MACDONALD, RJ ;
RUTTER, WJ .
BIOCHEMISTRY, 1979, 18 (24) :5294-5299