A COMPREHENSIVE REVIEW OF NALOXANE FOR THE EMERGENCY PHYSICIAN

被引:87
作者
CHAMBERLAIN, JM
KLEIN, BL
机构
[1] Emergency Medical Trauma Center, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC
关键词
NALOXONE; OPIOIDS; OPIOID ANTAGONISTS;
D O I
10.1016/0735-6757(94)90033-7
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Naloxone has enjoyed long-standing success as a safe and effective opioid antagonist and has been invaluable in defining the role of endogenous opioid pathways in the response to pathological states such as sepsis and hypovolemia. We look forward to exciting research to further elucidate these pathways and to improve outcome by modulating the patient's physiological response to these stresses. © 1994.
引用
收藏
页码:650 / 660
页数:11
相关论文
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[1]  
Litovitz, Holm, Clancy, Et al., 1992 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System, The American Journal of Emergency Medicine, 11, pp. 494-555, (1993)
[2]  
Evans, Hogg, Lunn, Et al., A comparative study of the narcotic agonist activity of naloxone and levallorphan, Anaesthesia, 29, pp. 721-727, (1974)
[3]  
Bradberry, Raebel, Continuous infusion of naloxone in the treatment of narcotic overdose, Drug Interlligence and Clinical Pharmacy, 15, pp. 945-950, (1981)
[4]  
Handal, Schauben, Salamone, Naloxone, Annals of Emergency Medicine, 12, pp. 438-445, (1983)
[5]  
Fishman, Roffwarg, Hellman, Disposition of naloxone-7,8-<sup>3</sup>H in normal and narcotic-dependent men, J Pharmacol Exp Ther, 187, pp. 575-580, (1973)
[6]  
Weinstein, Pfeffer, Schor, Et al., Absorption and distribution of naloxone in rats after oral and intravenous administration, Journal of Pharmaceutical Sciences, 62, pp. 1416-1419, (1973)
[7]  
Berkowitz, Ngal, Hempstead, Et al., Disposition of naloxone: use of a new radioimmunoassay., J Pharmacol Exp Ther, 195, pp. 499-504, (1975)
[8]  
Berkowitz, The Relationship of Pharmacokinetics to Pharmacological Activity, Clinical Pharmacokinetics, 1, pp. 219-230, (1976)
[9]  
Greenberg, Robert, Baskin, Endotracheal naloxone reversal of morphine-induced respiratory depression in rabbits, Annals of Emergency Medicine, 9, pp. 289-292, (1980)
[10]  
Tandberg, Abercrombie, Treatment of heroin overdose with endotracheal naloxone, Annals of Emergency Medicine, 11, pp. 443-445, (1982)