POTENTIAL BIOLOGICAL TARGETS FOR ANTI-ALZHEIMER DRUGS

被引:13
作者
ALLAIN, H
BELLIARD, S
DECERTAINES, J
BENTUEFERRER, D
BUREAU, M
LACROIX, P
机构
[1] HOP PONTCHAILLOU,SERV NEUROL,RENNES,FRANCE
[2] FAC MED RENNES,RESONANCE MAGNET BIOL & MED LAB,RENNES,FRANCE
[3] BIOTRIAL SA,RENNES,FRANCE
来源
DEMENTIA | 1993年 / 4卷 / 06期
关键词
ALZHEIMERS DISEASE; PHYSIOPATHOLOGY; CLINICAL TRIALS;
D O I
10.1159/000107344
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The stunning accumulation of data on the physiopathology of Alzheimer's disease is a real hinderance to pharmacologists who have to make decisions as to what molecules should be assessed first in man. Considering the cumbersomeness and cost of clinical trials in that field, a review of potential targets for drugs that are supposed to be active against the disease has become necessary, for a true definition of the rational justifications of trials to be envisaged.
引用
收藏
页码:347 / 352
页数:6
相关论文
共 63 条
[21]   N-METHYL-D-ASPARTATE ANTAGONISTS IN THE TREATMENT OF PARKINSONS-DISEASE [J].
GREENAMYRE, JT ;
OBRIEN, CF .
ARCHIVES OF NEUROLOGY, 1991, 48 (09) :977-981
[22]   NOVEL INHIBITORS OF IRON-DEPENDENT LIPID-PEROXIDATION FOR NEURODEGENERATIVE DISORDERS [J].
HALL, ED .
ANNALS OF NEUROLOGY, 1992, 32 :S137-S142
[23]   AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE [J].
HARDY, J ;
ALLSOP, D .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) :383-388
[24]   ALZHEIMERS-DISEASE - THE AMYLOID CASCADE HYPOTHESIS [J].
HARDY, JA ;
HIGGINS, GA .
SCIENCE, 1992, 256 (5054) :184-185
[25]   OKADAIC ACID INDUCES HYPERPHOSPHORYLATED FORMS OF TAU PROTEIN IN HUMAN BRAIN-SLICES [J].
HARRIS, KA ;
OYLER, GA ;
DOOLITTLE, GM ;
VINCENT, I ;
LEHMAN, RAW ;
KINCAID, RL ;
BILLINGSLEY, ML .
ANNALS OF NEUROLOGY, 1993, 33 (01) :77-87
[26]  
HENDERSON V, 1989, J NEUROSURG, V79, P335
[27]   THE CHOLINERGIC MODEL OF DEMENTIA, ALZHEIMER TYPE - PROGRESSION FROM THE UNITARY TRANSMITTER CONCEPT [J].
HOLTTUM, JR ;
GERSHON, S .
DEMENTIA, 1992, 3 (03) :174-185
[28]   AMMONIA IS ENDOGENOUSLY GENERATED IN THE BRAIN IN THE PRESENCE OF PRESUMED AND VERIFIED DEMENTIA OF ALZHEIMER TYPE [J].
HOYER, S ;
NITSCH, R ;
OESTERREICH, K .
NEUROSCIENCE LETTERS, 1990, 117 (03) :358-362
[29]   THE SEMINAL ROLE OF BETA-AMYLOID IN THE PATHOGENESIS OF ALZHEIMER-DISEASE [J].
JOACHIM, CL ;
SELKOE, DJ .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 1992, 6 (01) :7-34
[30]   ALZHEIMER PLAQUES AND TANGLES - ADVANCES ON BOTH FRONTS [J].
KOSIK, KS .
TRENDS IN NEUROSCIENCES, 1991, 14 (06) :218-219