DIURNAL REGULATION OF PER REPEAT MESSENGER-RNA IN THE SUPRACHIASMATIC NUCLEUS IN RAT-BRAIN

被引：19
作者：
ISHIDA, N
NOJI, S
ONO, K
KOYAMA, E
NOHNO, T
TANIGUCHI, S
TOKUNAGA, A
FUJII, T
MITSUI, Y
机构：
[1] OKAYAMA UNIV, SCH DENT,DEPT BIOCHEM,2-5-1 SHIKATA CHO, OKAYAMA 700, JAPAN
[2] AGCY IND SCI & TECHNOL, FERMENTAT RES INST,DIV CELL SCI & TECHNOL, TSUKUBA, JAPAN
[3] OKAYAMA UNIV, DEPT ORAL & MAXILLOFACIAL SURG 1, OKAYAMA 700, JAPAN
[4] KAWASAKI MED SCH, DEPT PHARMACOL, KURASHIKI, OKAYAMA 70101, JAPAN
[5] OKAYAMA UNIV, SCH MED,DEPT ANAT, OKAYAMA 700, JAPAN
来源：
NEUROSCIENCE LETTERS | 1991年 / 122卷 / 01期
关键词：
CIRCADIAN RHYTHM; MESSENGER RNA FLUCTUATION; INSITU HYBRIDIZATION; PERIOD REPEAT SEQUENCE; SUPRACHIASMATIC NUCLEUS; RAT BRAIN;
D O I：
10.1016/0304-3940(91)90206-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Per repeat is a rodent genomic DNA fragment which is homologous to the Gly-Thr repetitive amino acid sequence of the Drosophila clock gene 'period'. This study examined the temporal and spatial expression of the per repeat mRNA in rat brain. Northern blot analysis showed that the level of per repeat mRNA species fluctuates under light-dark cycle conditions in rat brain. Furthermore, the fluctuation of per repeat mRNA was clearly observed in the suprachiasmatic nucleus, but not so in other regions including the hippocampus as shown by in situ hybridization. The above results suggest that the Gly-Thr repetitive sequence also plays an important role in the circadian rhythm of mammals.
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页码：113 / 116
页数：4
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