DETECTION OF A SHARED IDIOTOPE ON 2 ENCEPHALOMYOCARDITIS VIRUS NEUTRALIZING MONOCLONAL-ANTIBODIES BY NEUTRALIZATION INHIBITION ENZYME-IMMUNOASSAY

被引：1

作者：

KRAAIJEVELD, CA

OOSTERLAKEN, TAM

VLASPOLDER, F

VANDIJK, PW

HARMSEN, M

FERNANDEZ, IM

BENAISSATROUW, BJ

SNIPPE, H

机构：

[1] Eijkman- Winkler Laboratory for Medical Microbiology, 3584 CX Utrecht, Utrecht University. Heidelberglaan 100

来源：

JOURNAL OF VIROLOGICAL METHODS | 1993年 / 44卷 / 2-3期

关键词：

ENCEPHALOMYOCARDITIS VIRUS; ANTIIDIOTYPIC ANTIBODY; ANTI-ANTI-IDIOTYPIC ANTIBODY; IDIOTYPIC CROSS-REACTIVITY; VIRUS NEUTRALIZATION;

D O I：

10.1016/0166-0934(93)90066-Z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Idiotypic cross-reactivity between encephalomyocarditis virus (EMCV) neutralizing monoclonal antibodies UM 21.1 (IgG2b) and UM 21.3 (IgG2a) was detected by neutralization inhibition enzyme immunoassay using polyclonal and monoclonal anti-idiotypic antibodies. One strongly cross-reactive anti-idiotypic monoclonal antibody, designated 21.1A5 (IgG2b), might recognize a recurrent idiotope on EMCV neutralizing antibodies but it did not induce EMCV neutralizing anti-anti-idiotypic antibodies in homologous BALB/c mice.

引用

页码：319 / 328

页数：10

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